Nonlinear Changes of Transmembrane Potential During Electrical Shocks
نویسندگان
چکیده
منابع مشابه
Nonlinear changes of transmembrane potential during electrical shocks: role of membrane electroporation.
Defibrillation shocks induce nonlinear changes of transmembrane potential (DeltaVm) that determine the outcome of defibrillation. As shown earlier, strong shocks applied during action potential plateau cause nonmonotonic negative DeltaVm, where an initial hyperpolarization is followed by Vm shift to a more positive level. The biphasic negative DeltaVm can be attributable to (1) an inward ionic ...
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Organization of cardiac tissue into cell strands and layers has been implicated in changes of transmembrane potential (DeltaV(m)) during defibrillation. To determine the shock-induced DeltaV(m) in such structures, cell strands of variable width [strand width (SW) = 0.15-2 mm] were grown in culture. Uniform-field shocks with variable strength [shock strength (SS) = 2-50 V/cm] were applied across...
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Transmembrane potential change (Δ V m) during shocks was recorded by a double-barrel microelectrode in 12 isolated guinea pig papillary muscles. After 10 S1 stimuli, square-wave S2 shocks of both polarities were given consisting of 10-ms monophasic and 10/10-ms and 5/5-ms biphasic waveforms that created potential gradients from 1.1 ± 0.3 to 11.9 ± 0.4 V/cm. S2 shocks were applied with 30, 60- t...
متن کاملDose-dependent reduction of cardiac transmembrane potential by high-intensity electrical shocks.
Cardiac tissue dysfunction can result from high-intensity electrical shocks and is manifested as changes in transmembrane potential ( V m). Ten-millisecond shock pulses (SPs) of varying intensity and polarity were applied to frog ventricle in diastole, and V m was quantified directly under the stimulating electrode by an optical method using voltage-sensitive dye. As SP intensities were increas...
متن کاملEffects of electroporation on optically recorded transmembrane potential responses to high-intensity electrical shocks.
The outcome of defibrillation shocks is determined by the nonlinear transmembrane potential (DeltaVm) response induced by a strong external electrical field in cardiac cells. We investigated the contribution of electroporation to DeltaVm transients during high-intensity shocks using optical mapping. Rectangular and ramp stimuli (10-20 ms) of different polarities and intensities were applied to ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2004
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000111526.69133.de